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Dipeptidyl peptidase-4 inhibitors inhibit dipeptidyl peptidase-4 and thus reduce glucagon and blood glucose levels. In , the stock of Avandamet was removed from the market, after inspections showed the factory where it was produced was violating good manufacturing practices. Archived from the original on March 19, Journal of Clinical Endocrinology and Metabolism. This difference from baseline between control and intervention groups diminished over time, but a significant difference in weight was maintained through year 9, the end of the study. In women, estrogen is believed to cause fat to be stored in the buttocks , thighs , and hips. Hepatitis A is a self-limiting disorder; you may need only rest and plenty of fluids to get over it.
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One of the few studies conducted on the subject did not find that beer drinkers are more prone to central obesity than nondrinkers or drinkers of wine or spirits. These symptoms can suggest the appearance of central obesity. Deposits of excess fat at the sides of one's waistline are commonly referred to as "love handles". Researchers in Copenhagen examined the relationship between waist circumferences and costs among 31, subjects aged 50—64 years of age with different waist circumferences.
Their study showed that an increase in just an additional centimetre above normal waistline caused a 1. From Wikipedia, the free encyclopedia. Central obesity Synonyms beer belly, beer gut, pot belly, spare tyre, bread box A centrally obese male.
The body mass index is Specialty Endocrinology Abdominal obesity , also known as central obesity , occurs when excessive abdominal fat around the stomach and abdomen has built up to the extent that it is likely to have a negative impact on health. Current Opinion in Lipidology. Retrieved on April 9, Dementia and Geriatric Cognitive Disorders.
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International Journal of Hypertension. Expert Review of Cardiovascular Therapy. Metabolic Syndrome and Related Disorders. Journal of Association of Physicians of India. Journal of Medical Biochemistry. Increasing trends in waist circumference and abdominal obesity among US adults. Am J Clin Nutr. A case of comparing apples and pears? Journal of Sex Research. Why are women so superior? The Ancel Keys Lecture". Archived from the original on February 9, The Wall Street Journal.
Archived from the original on 11 October Retrieved 8 October Archived from the original on 25 January Abbott Laboratories in Germany. Archived from the original on 14 October Food and Drug Administration of Thailand. Archived from the original PDF on May 11, Evaluating the Evidence for a Paradigm Shift". Liquid metformin is sold under the name Riomet in India. Metformin IR immediate release is available in , , and mg tablets.
All of these are available as generic medications in the U. Metformin SR slow release or XR extended release was introduced in It is available in , , and mg strengths, mainly to counteract common gastrointestinal side effects, as well as to increase compliance by reducing pill burden. No difference in effectiveness exists between the two preparations. When used for type 2 diabetes, metformin is often prescribed in combination with other medications.
Several are available as fixed-dose combinations , to reduce pill burden and simplify administration. A combination of metformin and rosiglitazone was released in and sold as Avandamet by GlaxoSmithKline. By it had become the most popular metformin combination. In , the stock of Avandamet was removed from the market, after inspections showed the factory where it was produced was violating good manufacturing practices.
However, following a meta-analysis in that linked the medication's use to an increased risk of heart attack ,  concerns were raised over the safety of medicines containing rosiglitazone.
In September the European Medicines Agency EMA recommended that the medication be suspended from the European market because the benefits of rosiglitazone no longer outweighed the risks. In November , the FDA lifted its earlier restrictions on rosiglitazone after reviewing the results of the RECORD clinical trial a six-year, open label randomized control trial , which failed to show elevated risk of heart attack or death associated with the medication.
Dipeptidyl peptidase-4 inhibitors inhibit dipeptidyl peptidase-4 and thus reduce glucagon and blood glucose levels. In Europe, Canada, and elsewhere metformin combined with linagliptin is marketed under the trade name Jentadueto.
Sulfonylureas act by increasing insulin release from the beta cells in the pancreas. Metformin is available combined with the sulfonylureas glipizide Metaglip and glibenclamide US: Meglitinides are similar to sulfonylureas. The combination of metformin with pioglitazone and glibenclamide  is available in India as Triformin. From Wikipedia, the free encyclopedia. B No risk in non-human studies. S4 Prescription only CA: Pharmacy and pharmacology portal Medicine portal.
Clinical Pharmacology and Therapeutics. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus". Archived from the original on 24 December Retrieved 2 January A Systematic Review and Meta-analysis".
Annals of Internal Medicine. Archived from the original on Archived PDF from the original on First choice for monotherapy: Analogue-based Drug Discovery II. Herb, nutrient, and drug interactions: Archived PDF from the original on 13 December Retrieved 8 December Archived from the original on 3 August Retrieved 11 January Blake; Stanifer, John W. Diab Vasc Dis Res. International Journal of Obesity. The Cochrane Database of Systematic Reviews.
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Royal College of Obstetricians and Gynaecologists. Scientific Advisory Committee Opinion Paper Archived from the original PDF on European Journal of Endocrinology. Acta Obstetricia et Gynecologica Scandinavica.
Journal of Human Reproductive Sciences. Diabetes research and clinical practice. A Systematic Review and Meta-Analysis". The Scientific World Journal. British Journal of Clinical Pharmacology. This article incorporates text by Dan J. Siskind, Janni Leung, Anthony W. Royal College of Radiologists. Retrieved October 26, through the Internet Archive.
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